瞭望前瞻丨SABCS 2025盛幕将启,中国之声亮相世界舞台(Poster Session 4精选)

作者:肿瘤瞭望   日期:2025/12/8 14:20:42  浏览量:159

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第48届圣安东尼奥乳腺癌研讨会(SABCS 2025)将于当地时间2025年12月9-12日在美国得克萨斯州圣安东尼奥Henry B.Gonzalez Convention Center举行。作为乳腺癌领域的顶级盛会,SABCS聚焦乳腺癌生物学、病因、预防、诊断及治疗前沿,促进临床、转化与基础研究的深度融合,为全球科研人员提供交流协作与专业成长的平台。肿瘤瞭望-乳腺时讯特别对Rapid Fire、Poster Spotlight、Poster Session等环节中国专家的报告内容进行汇总,以便读者快速了解会议动态。本文将介绍Poster Session 4环节入选中国研究,敬请关注后续详细报道!(注:如有遗漏或错误,欢迎留言指正。)

编者按:第48届圣安东尼奥乳腺癌研讨会(SABCS 2025)将于当地时间2025年12月9-12日在美国得克萨斯州圣安东尼奥Henry B.Gonzalez Convention Center举行。作为乳腺癌领域的顶级盛会,SABCS聚焦乳腺癌生物学、病因、预防、诊断及治疗前沿,促进临床、转化与基础研究的深度融合,为全球科研人员提供交流协作与专业成长的平台。肿瘤瞭望-乳腺时讯特别对Rapid Fire、Poster Spotlight、Poster Session等环节中国专家的报告内容进行汇总,以便读者快速了解会议动态。本文将介绍Poster Session 4环节入选中国研究,敬请关注后续详细报道!(注:如有遗漏或错误,欢迎留言指正。)
 
Poster Session 4
时间:12月11日5:00 PM–6:30 PM CST
地点:Exhibit Hall
 
摘要号:PS4-01-23
Transcriptomic Profiling and Immune-metabolic Prediction Model Construction for Neoadjuvant Chemotherapy Response in Triple-Negative Breast Cancer Patients
三阴性乳腺癌患者新辅助化疗反应的转录组分析和免疫代谢预测模型构建
讲者:Shuning Ding(上海交通大学医学院附属第一人民医院)
 
摘要号:PS4-01-25
Noninvasive Early Detection of Breast Cancer via Copy Number Variation Profiling of Nipple Discharge DNA
通过乳头溢液DNA的拷贝数变异分析进行乳腺癌的无创早期检测
讲者:Wen Wen(中国医学科学院肿瘤医院)
 
摘要号:PS4-02-04
Revealing the prognostic significance of dephosphorylation-related genes in breast cancer:comprehensive insightsbased on bulk RNAsequencingand single-cell RNA sequencingdata
揭示去磷酸化相关基因在乳腺癌中的预后意义:基于批量RNA测序和单细胞RNA测序数据的全面见解
讲者:Chen Wei(福建医科大学胜利临床医学院)
 
摘要号:PS4-02-12
Combination of CDK4/6 and EZH2 Inhibitors Enhances Anti-Tumor Immunity in Triple-Negative Breast Cancer via the MAVS-TBK1-STAT1 Signaling Pathway and Synergizes with Anti-PD-1 Therapy
CDK4/6和EZH2抑制剂联合治疗通过MAVS-TBK1-STAT1信号通路增强三阴性乳腺癌的抗肿瘤免疫,并与抗PD-1疗法协同作用
讲者:Sisi Li(重庆大学附属肿瘤医院)
 
摘要号:PS4-02-13
Genes from epithelial-mesenchymal transition predict overall survival effectively in breast cancer:anovel risk model based on initial step of tumor metastasis
来自上皮间质转化的基因可有效预测乳腺癌的总生存率:基于肿瘤转移初始步骤的新风险模型
讲者:陈伟贤(常州市第二人民医院)
 
摘要号:PS4-02-14
Recognition of immunogenomic signature and prognostic value of the subtype of epithelial-mesenchymal transition in breast cancer
识别乳腺癌上皮间质转化亚型的免疫基因组特征和预后价值
讲者:陈伟贤(常州市第二人民医院)
 
摘要号:PS4-02-15
Sumo e3 ligase ranbp2 affects triple-negative breast cancer tumorigenicity by stabilizing birc5 expression
SUMO E3连接酶RanBP2通过稳定BIRC5表达影响三阴性乳腺癌的致瘤性
讲者:Yuxiang Lin(福建医科大学附属协和医院)
 
摘要号:PS4-02-22
Dynamics of the Intratumoral Microbiome Across Malignant Transformation and Treatment in Breast Cancer
乳腺癌恶性转化和治疗过程中肿瘤内微生物组的动态变化
讲者:liuliu quan(中国医学科学院肿瘤医院)
 
摘要号:PS4-02-26
Gper signaling as a biomarker for endocrine therapy sensitivity in pik3ca mutant hr+advanced breast cancer
Gper信号作为PIK3CA突变HR+晚期乳腺癌内分泌治疗敏感性的生物标志物
讲者:Tenghua Yu(江西省肿瘤医院)
 
摘要号:PS4-02-27
Machine learning-enhanced ultra-deep sequencing for low-abundance circulating tumor DNA(ctDNA)in breast cancer
机器学习增强的乳腺癌低丰度循环肿瘤DNA(ctDNA)超深度测序
讲者:Yuwei Ni(燃石生物科技有限公司)
 
摘要号:PS4-03-04
Hmgcs2 promotes malignant phenotype and apatinib resistance in her2-negative breast cancer via the rab23/β-catenin/tcf signaling axis
Hmgcs2通过rab23/β-catenin/tcf信号轴促进HER2阴性乳腺癌的恶性表型和阿帕替尼耐药
讲者:Jing Wu(重庆大学附属肿瘤医院)
 
摘要号:PS4-03-05
Reversal of TNBC Radiotherapy Resistance via LYTAC-Induced Ferroptosis Through Selective SDC1 Degradation
通过LYTAC诱导的铁死亡选择性降解SDC1逆转三阴性乳腺癌放疗抵抗
讲者:Min Wei(浙江大学医学院附属第一医院)
 
摘要号:PS4-03-27
M2 Macrophages Predict Response to Neoadjuvant Chemotherapy in Triple Negative Breast Cancer Patients
M2巨噬细胞可预测三阴性乳腺癌患者对新辅助化疗的应答
讲者:陈伟贤(常州市第二人民医院)
 
摘要号:PS4-03-28
Hypoxia and lactate metabolism-relatedgene signature for prognosis prediction in triple negative breast cancerand hub gene COL5A3 promotes cancer progressionvia PI3K/AKT pathway
缺氧和乳酸代谢相关基因在三阴性乳腺癌预后预测中的作用,核心基因COL5A3通过PI3K/AKT通路促进肿瘤进展
讲者:陈伟贤(常州市第二人民医院)
 
摘要号:PS4-05-07
Integrated Genomic Profiling Identifies Predictive Biomarkers for Neoadjuvant Therapy Response in Chinese Breast Cancers
整合基因组谱识别中国乳腺癌新辅助治疗反应的预测性生物标志物
讲者:王中华(复旦大学附属肿瘤医院)
 
摘要号:PS4-05-08
Perineural invasion increases the risk of lymph node metastasis in early-stage operable breast cancer:a large-scale propensity-matched cohort study and meta-analysis
神经浸润增加早期可手术乳腺癌的淋巴结转移风险:一项大规模倾向匹配队列研究和荟萃分析
讲者:Weifeng Cai(福建医科大学附属协和医院)
 
摘要号:PS4-05-16
Multi-omics analysis identifies EFR3B as a driver of chemoresistance in breast cancer through epithelial-endothelial cell communication
多组学分析确定EFR3B是通过上皮-内皮细胞沟通导致乳腺癌化疗耐药的驱动因素
讲者:Yilong Lin(厦门大学附属第一医院)
 
摘要号:PS4-05-18
The predictive value of tumor-to-gland density ratio in pathological complete response to Neoadjuvant chemotherapy in breast cancer
肿瘤与腺体密度比值对乳腺癌新辅助化疗后病理完全缓解的预测价值
讲者:毛晓韵(中国医科大学第一附属医院)
 
摘要号:PS4-04-01
A 15-Gene Predictive Signature for Pathologic Complete Response in Triple-Negative Breast Cancer:Validation Across Institutional and TCGA Cohorts
三阴性乳腺癌病理完全缓解的15基因预测标签:机构和TCGA队列的验证
讲者:Chi-Wen Luo(高雄医科大学附属医院)
 
摘要号:PS4-04-05
Construction and validation of a clinical model predicting pathological complete response after neoadjuvant immunotherapy in breast cancer
乳腺癌新辅助免疫治疗后病理完全缓解预测临床模型的构建与验证
讲者:Min Lin(中山大学肿瘤防治中心)
 
摘要号:PS4-04-16
Discovering potential drug targets for estrogen receptor-positive breast cancer through Mendelian randomization
通过孟德尔随机化发现雌激素受体阳性乳腺癌的潜在药物靶点
讲者:Chen Wei(福建医科大学胜利临床医学院)
 
摘要号:PS4-04-28
Multifunctional lipid nanoparticles remodeling tumor immune microenvironment for breast cancer chemio-immunotherapy
多功能脂质纳米颗粒重塑肿瘤免疫微环境用于乳腺癌化学免疫治疗
讲者:Huiying Fang(重庆大学附属肿瘤医院)
 
摘要号:PS4-06-06
Tfx06 dose expansion study showed favorable safety and efficacy in patients with er+/her2–breast cancer in a phase 2 study
Tfx06剂量扩展研究在ER+/HER2-乳腺癌患者中显示出良好的安全性和有效性
讲者:Charles Z Ding(杭州扬利医药科技有限公司)
 
摘要号:PS4-06-17
First clinical data of DB-1310(HER3-targeted antibody-drug-conjugate),in patients with pretreated hormone receptor-positive/HER2-negative breast cancer:efficacy and safety data from a phase 1/2a trial
DB-1310(靶向HER3的抗体-药物偶联物)治疗既往经治的HR+/HER2-乳腺癌患者的首次临床数据:1/2a期试验的疗效和安全性数据
讲者:Hua Mu(映恩生物)
 
摘要号:PS4-10-03
Programmed cell death ligand 1(PD-L1)expression profiles of early-stage triple-negative breast cancer(TNBC)in China:a retrospective observational study
中国早期三阴性乳腺癌(TNBC)患者程序性细胞死亡配体1(PD-L1)表达谱:一项回顾性观察性研究
讲者:Jiali Wang(默沙东中国)
 
摘要号:PS4-10-29
Diverse adjuvant treatment in triple-negative breast cancer patients with residual disease after neoadjuvant chemotherapy:A single center real-world study
新辅助化疗后残留病灶的三阴性乳腺癌患者的多样化辅助治疗:一项单中心真实世界研究
讲者:Xi Chen(中国医学科学院肿瘤医院)
 
摘要号:PS4-08-02
Prognosis and Management of DCIS with Microinvasion:Insights from SEER Database and a Chinese Cohort
DCIS微浸润的预后和管理:来自SEER数据库和中国队列的见解
讲者:杨雅平(中山大学孙逸仙纪念医院)
 
摘要号:PS4-08-03
An Exploratory Clinical Study for Neoadjuvant Treatment of HER2-low Expressing,Stage II-III Breast Cancer with Vedolizumab in Combination with Pembrolizumab
一项针对维多珠单抗联合帕博利珠单抗用于HER2低表达II-III期乳腺癌新辅助治疗的探索性临床研究
讲者:罗婷(四川大学华西医院)
 
摘要号:PS4-08-06
Optimizing Postoperative Adjuvant Therapy for Early-Stage Breast Cancer by Combining Dynamic ctDNA MRD Monitoring with Clinical Risk Stratification:An Open-label,Multicenter,Prospective Study(AMENDER)
结合动态ctDNA MRD监测和临床风险分层优化早期乳腺癌术后辅助治疗:一项开放标签、多中心、前瞻性研究(AMENDER)
讲者:马飞(中国医学科学院肿瘤医院)
 
摘要号:PS4-08-09
Long-term outcomes and prognostic factors in metaplastic breast cancer treated with curative intent:a 22-year multicenter retrospective cohort study
化生性乳腺癌根治性治疗的长期结果和预后因素:一项22年的多中心回顾性队列研究
讲者:Sze Wa Shirley Tse(香港伊丽莎白医院)
 
摘要号:PS4-08-18
Tailoring escalated adjuvant chemotherapy for multifocal and multicentric breast cancer with low tumor burden
针对低肿瘤负荷的多灶性和多中心乳腺癌量身定制升级辅助化疗
讲者:Yizi Zheng(温州医科大学附属第一医院)
 
摘要号:PS4-08-28
Patient-reported outcomes of adjuvant therapy with CDK4/6 inhibitors for HR+/HER2-early breast cancer:a retrospective cohort study
CDK4/6抑制剂辅助治疗HR+/HER2-早期乳腺癌的患者报告结局:一项回顾性队列研究
讲者:王永胜(山东省肿瘤医院)
 
摘要号:PS4-11-09
Axillary Management Strategies in Breast Cancer Patients With ypN0 After Neoadjuvant Therapy
新辅助治疗后ypN0乳腺癌患者的腋窝管理策略
讲者:Qingyao Shang(中国医学科学院肿瘤医院)
 
摘要号:PS4-09-27
Global inequalities in female breast cancer burden by decomposition and age-period-cohort analysis,1990-2021
1990-2021年全球女性乳腺癌负担差异解析:基于年龄-时期-队列模型的分解研究
讲者:Ke Li(北京大学人民医院)
 
摘要号:PS4-11-14
Anthracycline-based Systemic Chemotherapy on Long-term Prognosis of Metaplastic Breast Cancer:A Real World Study with 637 Cases in 14 multi-center
基于蒽环类药物的全身化疗对化生性乳腺癌长期预后的影响:一项来自14个多中心637例患者的真实世界研究
讲者:Can Zhou(西安交通大学第一附属医院)
 
摘要号:PS4-05-02
Rapid and ultrasensitive detection of surgical margin and metastatic lymph node via EpCAM-targeted surface-enhanced Raman scattering biosensor in breast cancer
通过EpCAM靶向的表面增强拉曼散射生物传感器快速和超灵敏地检测乳腺癌的手术切缘和转移淋巴结
讲者:Kangliang Lou(厦门大学医学院)
 
摘要号:PS4-10-05
Dsc3 suppresses the ccl21-pdc-treg axis to reprogram immunosuppressive microenvironment and potentiate immunotherapy in triple-negative breast cancer
Dsc3抑制CCL21-pDC-Treg轴以重编程免疫抑制微环境并增强三阴性乳腺癌的免疫治疗疗效
讲者:Yusong Wang(中国医科大学附属第一医院)

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